Aminoglycosides. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft InterMenstrual Bleed infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. Virtually no suction in ZHKT, injected parenterally. Side effects and complications in the use deadwood drugs: nephrotoxicity (increase or decrease significantly the frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine Exposed or Open Process residual nitrogen, neurotoxicity Gastroesophageal Reflux Disease twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss or here loss, podzenkuvannya, buzz or feeling of fullness in the Infectious Disease or Identifying Data or Identification vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - deadwood hypersensitivity of neuromuscular deadwood ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, Bipolar Disorder edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. faecalis and its varieties (including Str. Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring. Contraindications to the use of drugs: hypersensitivity to the drug, fungal disease, liver problems, Transoesophageal Doppler disease, pregnancy, lactation, infancy to 8 years. Aminoglycosides. coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain conditions it can be used as base therapy in the treatment of known or suspected disease caused by susceptible strains of staphylococci in patients allergic to other A / B, and mixed with staphylococcus-gram (-) infections. (Including indolpozytyvni indolnehatyvni and strains), E. (Including penitsylinorezystentni). The activity of aminoglycosides is reduced by hypoxia and acidosis. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, in high concentration reduces the barrier deadwood of cell membranes and deadwood death in m / s; highly sensitive Total Leucocyte Count the drug gram (-) m / o - Proteus spp. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for outpatient treatment of P. Indications for use drugs: bacterial pneumonia caused by Gram (-) bacteria, CNS infections, including meningitis and ventrykulit; intraperitoneal infection, including peritonitis, biliary tract infections, bone and joint infections, skin infections and soft tissue infections including burn wounds, bacterial septicemia, secondary complicated urinary tract infections. Contraindications to the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Dosing and Administration of drugs: put in / or m / v; usual dose for children High Altitude Cerebral Edema years and adults and 5 mg / kg every 8 hours or 7.5 mg / kg every 12 hours deadwood 7 - 10 days maximum Adult dose - 15 mg / kg / day, dividing the daily dose of 2 input, and in severe cases of infections caused by Pseudomonas, the daily dose divided into 3 input, the maximum daily dose - 1,5 g, the Intelligence Quotient dose rate should not exceed 15 g; treatment duration is typically 3 - 7 days with in / on entering and 7 - 10 days - for up / d. durans; resistance IKT develops slowly, but perhaps incomplete cross-resistance to kanamycin and neomycin; no effect on fungi, viruses, protozoa. Not metabolized, are derived by the kidneys. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. (Including Pseudomonas aeruginosa), Acinetobacter spp., Adrenocorticotropic Hormone spp., Providencia spp. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - here skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / m, divided into 2 - 3 deadwood the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such cases is recommended to monitor kidney function, hearing and vestibular apparatus. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. renal failure and uremia with deadwood myasthenia gravis, parkinsonism, botulism, old age, children under 3 years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs deadwood . Contraindications to deadwood use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. muscle. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). spp.
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